Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

Exploring the pole: an EMBO conference on centrosomes and spindle pole bodies

Nature Cell Biology volume 10, pages 1375–1378 (2008)Cite this article

Abstract

The centrosome and spindle pole body community gathered for its triennial meeting from 12–16 September, 2008 at EMBL in Heidelberg (Germany).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Centriole duplication pathway.

References

  1. Hagan, I.M. & Palazzo, R.E. Warming up at the poles. EMBO Rep. 7, 364–371 (2006).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Palazzo, R. Centrosome and spindle pole body dynamics. Cell Motil. Cytoskeleton 54, 148–194 (2003).

    Article  Google Scholar 

  3. Stearns, T. & Winey, M. The cell center at 100. Cell 91, 303–309 (1997).

    Article  CAS  PubMed  Google Scholar 

  4. Wigge, P.A. et al. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J. Cell Biol. 141, 967–977 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Andersen, J.S. et al. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570–574 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. Kittler, R. et al. Genome-scale RNAi profiling of cell division in human tissue culture cells. Nature Cell Biol. 9, 1401–1412 (2007).

    Article  CAS  PubMed  Google Scholar 

  7. Poser, I. et al. BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nature Methods 5, 409–415 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Goshima, G. et al. Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316, 417–421 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Dobbelaere, J. et al. A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila. PLoS Biol 6, e224 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kilburn, C.L. et al. New Tetrahymena basal body protein components identify basal body domain structure. J. Cell Biol. 178, 905–912 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Keller, L.C., Romijn, E.P., Zamora, I., Yates, J.R., III & Marshall, W.F. Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr. Biol. 15, 1090–1098 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Uetake, Y. et al. Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells. J. Cell Biol. 176, 173–182 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Nigg, E.A. Centrosome duplication: of rules and licenses. Trends Cell Biol. 17, 215–221 (2007).

    Article  CAS  PubMed  Google Scholar 

  14. Hiraki, M., Nakazawa, Y., Kamiya, R. & Hirono, M. Bld10p constitutes the cartwheel-spoke tip and stabilizes the 9-fold symmetry of the centriole. Curr. Biol. 17, 1778–1783 (2007).

    Article  CAS  PubMed  Google Scholar 

  15. Nakazawa, Y., Hiraki, M., Kamiya, R. & Hirono, M. SAS-6 is a cartwheel protein that establishes the 9-fold symmetry of the centriole. Curr. Biol. 17, 2169–2174 (2007).

    Article  CAS  PubMed  Google Scholar 

  16. Song, M., Aravind, L., Muller-Reichert, T. & O'Connell, K. The conserved protein SZY-20 opposes the Plk-4 related kinase ZYG-1 to limit centrosome size. Dev. Cell, advance online publication, 10.1016/j.devcel.2008.09.018 (2008).

  17. Pelletier, L., O'Toole, E., Schwager, A., Hyman, A.A. & Muller-Reichert, T. Centriole assembly in Caenorhabditis elegans. Nature 444, 619–623 (2006).

    Article  CAS  PubMed  Google Scholar 

  18. Dutcher, S.K. Finding treasures in frozen cells: new centriole intermediates. Bioessays 29, 630–4 (2007).

    Article  CAS  PubMed  Google Scholar 

  19. Sardon, T., Peset, I., Petrova, B. & Vernos, I. Dissecting the role of Aurora A during spindle assembly. EMBO J. 27, 2567–79 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Chan, E.H., Santamaria, A., Sillje, H.H. & Nigg, E.A. Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora. Chromosoma 117, 457–69 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Caydasi, A. & Pereira, G. Spindle alignment regulates the dynamic association of checkpoint proteins with yeast spindle pole bodies. Dev. Cell, advance online publication, 10.1016/j.devcel.2008.10.013 (2008).

  22. Chen, C.-T. et al. The SIN kinase Sid2 regulates cytoplasmic retention of the Cdc14-like phosphatase Clp1 in S. pombe. Curr. Biol. 18, 1594–1599 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Cheng, J. et al. Centrosome misorientation reduces stem cell division during ageing. Nature advance online publication, doi: 10.1038/nature07386 (2008).

  24. Bignold, L.P., Coghlan, B.L. & Jersmann, H.P. Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours. Cell Biol. Int. 30, 640–644 (2006).

    Article  CAS  PubMed  Google Scholar 

  25. Basto, R. et al. Centrosome amplification can initiate tumorigenesis in flies. Cell 133, 1032–1042 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Castellanos, E., Dominguez, P. & Gonzalez, C. Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr. Biol. 18, 1209–1214 (2008).

    Article  CAS  PubMed  Google Scholar 

  27. Kwon, M. et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 22, 2189–203 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Oakley, C.E. & Oakley, B.R. Identification of γ-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulans. Nature 338, 662–664 (1989).

    Article  CAS  PubMed  Google Scholar 

  29. Strnad, P. & Gonczy, P. Mechanisms of procentriole formation. Trends Cell Biol. 18, 389–396 (2008).

    Article  CAS  PubMed  Google Scholar 

  30. Bettencourt-Dias, M. & Glover, D.M. Centrosome biogenesis and function: centrosomics brings new understanding. Nature Rev. Mol. Cell Biol. 8, 451–463 (2007).

    Article  CAS  Google Scholar 

  31. Azimzadeh, J. & Bornens, M. Structure and duplication of the centrosome. J. Cell Sci. 120, 2139–2142 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MO 64110 USA and in the Department of Molecular and Integrative Physiology, Sue L. Jaspersen is at the Stowers Institute for Medical Research, Kansas City, University of Kansas Medical Center, Kansas City, KS 66160 USA. slj@stowers-institute.org,

    Sue L. Jaspersen

  2. Tim Stearns is in the Department of Biology, CA 94305 USA and in the Department of Genetics, Stanford University, Stanford, Stanford University School of Medicine, Stanford, CA 94305 USA. stearns@stanford.edu,

    Tim Stearns

Authors
  1. Sue L. Jaspersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tim Stearns
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jaspersen, S., Stearns, T. Exploring the pole: an EMBO conference on centrosomes and spindle pole bodies. Nat Cell Biol 10, 1375–1378 (2008). https://doi.org/10.1038/ncb1208-1375

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1208-1375

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing