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S100 chemokines mediate bookmarking of premetastatic niches

Nature Cell Biology volume 8, pages 1321–1323 (2006)Cite this article

Primary tumours release soluble factors, including VEGF-A, TGFβ and TNFα, which induce expression of the chemokines S100A8 and S100A9 in the myeloid and endothelial cells within the lung before tumour metastasis. These chemokine-activated premetastatic niches support adhesion and invasion of disseminating malignant cells, thereby establishing a fertile habitat for metastatic tumours.

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Figure 1: Establishment of a premetastatic niche by tumour cells.

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Authors and Affiliations

  1. Genetic Medicine and Pediatric Oncology Department, Howard Hughes Medical Institute, Weill Cornell Medical College, New York, 10021, NY, USA

    Shahin Rafii & David Lyden

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  1. Shahin Rafii
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  2. David Lyden
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Rafii, S., Lyden, D. S100 chemokines mediate bookmarking of premetastatic niches. Nat Cell Biol 8, 1321–1323 (2006). https://doi.org/10.1038/ncb1206-1321

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