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A second RING to destroy p27Kip1

Nature Cell Biology volume 6, pages 1153–1155 (2004)Cite this article

The cell cycle regulator p27Kip1 must be degraded to permit cell division. Degradation is moderate in G1 phase, but is enhanced in S-phase. Now, a novel ubiquitin ligase that can ubiquitinate p27 leading to its proteolysis after mitogen stimulation has been identified.

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Figure 1: Consecutive ubiquitination pathways regulate p27 proteolysis before and after the G1–S transition.

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  1. the Max-Planck-Institute for Biochemistry, Am Klopferspitz 18, Martinsried, D-82152, Germany

    Ludger Hengst

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  1. Ludger Hengst
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Hengst, L. A second RING to destroy p27Kip1. Nat Cell Biol 6, 1153–1155 (2004). https://doi.org/10.1038/ncb1204-1153

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