Work in this issue advances our understanding of how the small G protein Cdc42 functions to polarize budding yeast. Remarkably, Cdc42 can polarize in the absence of upstream cues or positive feedback from the cytoskeleton. Polarization requires the scaffold protein Bem1 and cycling of Cdc42 between its GTP- and GDP-bound states.
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Blumer, K., Cooper, J. Go ahead, break my symmetry!. Nat Cell Biol 5, 1048–1049 (2003). https://doi.org/10.1038/ncb1203-1048
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DOI: https://doi.org/10.1038/ncb1203-1048
