Calcium orchestrates apoptosis

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Apoptosis is a feature of many diseases and is critical for the sculpting and maintenance of tissues. New work demonstrates that calcium released from the endoplasmic reticulum synchronizes the mass exodus of cytochrome c from the mitochondria, a phenomenon that coordinates apoptosis.

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Figure 1: The roles of calcium and cytochrome c as inter-organellar messengers in apoptosis.

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