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An unlikely player joins the ATM signalling network

Nature Cell Biology volume 2, pages E215–E216 (2000)Cite this article

ATM, the product of the gene that is mutated in the human genetic disorder ataxia telangiectasia (A-T), responds to DNA damage by phosphorylating several key substrates that are involved in both the sensing of damage and the activation of cell-cycle checkpoints. The unexpected activation of ATM kinase in response to insulin supports a more general signalling role for this enzyme.

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Figure 1: Activation of ATM kinase by insulin and a DNA-damaging agent (ionizing radiation).

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  1. joint appointment at the Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia

    Martin F. Lavin

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  1. Martin F. Lavin
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Lavin, M. An unlikely player joins the ATM signalling network. Nat Cell Biol 2, E215–E216 (2000). https://doi.org/10.1038/35046628

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