Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Axonal microtubules stay put

Nature Cell Biology volume 1, pages E171–E173 (1999)Cite this article

Abstract

Direct visualization of individual axonal microtubules in Xenopus neurons indicates that they are primarily stationary, while another study shows that tubulin, the protein from which microtubules are made, can be transported in a non-microtubule form. Both results run contrary to a widely accepted model of slow axonal tubulin transport.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Fluorescence speckle microscopy (FSM).
Figure 2: Chang et al.’s experimental procedure4.
Figure 3: The expected results of following the behaviour of individual microtubules in live axons by fluorescence speckle microscopy.

References

  1. Bray, D. Trends Cell Biol. 7, 379 (1997).

    Article  CAS  Google Scholar 

  2. Baas, P. W. & Brown, A. Trends Cell Biol. 7, 380–384 (1997).

    Article  CAS  Google Scholar 

  3. Hirokawa, N., Terada, S., Funakoshi, T. & Takeda, S. Trends Cell Biol. 7, 384–388 (1997).

    Article  CAS  Google Scholar 

  4. Chang, S., Svitkina, T. M., Borisy, G. G. & Popov, S. V. Nature Cell Biol. 1, 399–403 (1999).

    Article  CAS  Google Scholar 

  5. Waterman-Storer, C. M. & Salmon, E. D. Biophys. J. 75, 2059–2069 ( 1998).

    Article  CAS  Google Scholar 

  6. Lasek, R. J. Trends Neurosci. 3, 87–91 (1980).

    Article  Google Scholar 

  7. Keating, T. J. et al. Proc. Natl Acad. Sci. USA 94, 5078– 5083 (1997).

    Article  CAS  Google Scholar 

  8. Waterman-Storer, C. M. & Salmon, E. D. J. Cell Biol. 139, 417–434 ( 1997).

    Article  CAS  Google Scholar 

  9. Tanaka, E. & Kirschner, M. W. J. Cell Biol. 115 , 345–363 (1991).

    Article  CAS  Google Scholar 

  10. Reinsch, S. S., Mitchison, T. J. & Kirschner, M. W. J. Cell Biol. 115, 365– 379 (1991).

    Article  CAS  Google Scholar 

  11. Chang, S., Rodionov, V. I. Borisy, G. G. & Popov, S. V. J. Neurosci. 18, 821–829 (1998).

    Article  CAS  Google Scholar 

  12. Baas, P. W. Neuron 22, 23–31 ( 1999).

    Article  CAS  Google Scholar 

  13. Sabry, J., O’Connor, T. P. & Kirschner, M. W. Neuron 14, 1247 –1256 (1995).

    Article  CAS  Google Scholar 

  14. Galbraith, J. A., Reese, T. S., Schlief, M. L & Gallant, P. E. Proc. Natl Acad. Sci. USA 96, 11589– 11594 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins , 80523, , Colorado, USA

    James R. Bamburg

  2. the Department of Biological Sciences, Purdue University, West Lafayette, 47906, Indiana , USA

    Peter J. Hollenbeck

Authors
  1. Peter J. Hollenbeck
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James R. Bamburg
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hollenbeck, P., Bamburg, J. Axonal microtubules stay put. Nat Cell Biol 1, E171–E173 (1999). https://doi.org/10.1038/15604

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/15604

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing