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TGF-β helps cells fly solo

Intravital imaging demonstrates that TGF-β signalling regulates the mode of cancer cell motility. Cells with active TGF-β signalling migrate as single cells and are capable of hematogenous and lymphatic spread, whereas cells lacking TGF-β signalling invade lymphatics collectively.

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Figure 1: Both single cell and collective cell motility can occur during cancer cell invasion and metastasis.

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Matise, L., Pickup, M. & Moses, H. TGF-β helps cells fly solo. Nat Cell Biol 11, 1281–1284 (2009). https://doi.org/10.1038/ncb1109-1281

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