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Spermidine surprise for a long life

Identifying therapies to slow down ageing and delay age-associated diseases is a primary goal of ageing-related research. Resveratrol and rapamycin were first found to promote longevity in yeast, and their effects were then extended to several organisms. Spermidine is a new longevity drug that can increase life span in yeast, nematodes and flies, possibly through an effect on chromatin-mediated regulation of gene expression.

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Figure 1: Spermidine synthesis and ageing.

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Kaeberlein, M. Spermidine surprise for a long life. Nat Cell Biol 11, 1277–1278 (2009). https://doi.org/10.1038/ncb1109-1277

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