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UCP2/3 — likely to be fundamental for mitochondrial Ca2+ uniport

Nature Cell Biology volume 10, pages 1237–1240 (2008)Cite this article

Trenker et al. reply:

Brookes et al. express doubts about our conclusions that UCP2/3 is involved in mitochondrial Ca2+ uptake1. Recently, there has been some scepticism about the uncoupling function of UCP2/3 (Refs 2,3,4, 5,6), and the mechanism by which these proteins exert their physiological effect is still controversial. Brookes et al. raised three points to argue against our conclusions.

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Figure 1: Correlation of mitochondrial Ca2+ uptake kinetics with UCP expression.
Figure 2: Characterization of mitochondria regarding their isolation.

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Acknowledgements

The laboratory is supported by the Austrian Science Funds (FWF, P20181-B05 and F3010-B05).

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  1. Institute for Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21/III, 8010, Graz, Austria

    Michael Trenker, Ismene Fertschai, Roland Malli & Wolfgang F. Graier

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  1. Michael Trenker
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  2. Ismene Fertschai
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  3. Roland Malli
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Correspondence to Wolfgang F. Graier.

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Trenker, M., Fertschai, I., Malli, R. et al. UCP2/3 — likely to be fundamental for mitochondrial Ca2+ uniport. Nat Cell Biol 10, 1237–1240 (2008). https://doi.org/10.1038/ncb1108-1237

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