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HtrA2 and Parkinson's disease: think PINK?

Nature Cell Biology volume 9, pages 1227–1229 (2007)Cite this article

Mitochondrial dysfunction is primarily responsible for neurodegeneration in Parkinson's disease. The Parkinson's-disease-associated kinase PINK1 has been identified as an important regulator of the activity of the mitochondria-associated stress-protective protease HtrA2.

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Figure 1: PINK1-dependent activation of HtrA2 protects against mitochondrial stress.

References

  1. Clausen, T., Southan, C. & Ehrmann, M. Mol. Cell 10, 443–455 (2002).

    Article  CAS  Google Scholar 

  2. Schlieker, C., Mogk, A. & Bukau, B. Cell 117, 417–419 (2004).

    Article  CAS  Google Scholar 

  3. Hegde, R. et al. J. Biol. Chem. 277, 432–438 (2002).

    Article  CAS  Google Scholar 

  4. Martins, L. M. et al. J. Biol. Chem. 277, 439–444 (2002).

    Article  CAS  Google Scholar 

  5. Verhagen, A. M. et al. J. Biol. Chem. 277, 445–454 (2002).

    Article  CAS  Google Scholar 

  6. Suzuki, Y. et al. Mol. Cell 8, 613–621 (2001).

    Article  CAS  Google Scholar 

  7. Jones, J.M. et al. Nature 425, 721–727 (2003).

    Article  CAS  Google Scholar 

  8. Martins, L. M. et al. Mol. Cell Biol. 24, 9848–9862 (2004).

    Article  CAS  Google Scholar 

  9. Strauss, K. M. et al. Hum. Mol. Genet. 14, 2099–2111 (2005).

    Article  CAS  Google Scholar 

  10. Plun-Favreau, H. et al. Nature Cell Biol. 9, 1243–1252 (2007).

    Article  CAS  Google Scholar 

  11. Li, W. et al. Nature Struct. Biol. 9, 436–441 (2002).

    Article  CAS  Google Scholar 

  12. Zhang, Y., Appleton, B. A., Wu, P., Wiesmann, C. & Sidhu, S. S. Protein Sci. 16, 1738–1750 (2007).

    Article  CAS  Google Scholar 

  13. Valente, E. M. et al. Science 304, 1158–1160 (2004).

    Article  CAS  Google Scholar 

  14. Kitada, T. et al. Proc. Natl Acad. Sci. USA 104, 11441–11446 (2007).

    Article  CAS  Google Scholar 

  15. Park, J. et al. Nature 441, 1157–1161 (2006).

    Article  CAS  Google Scholar 

  16. Clark, I. E. et al. Nature 441, 1162–1166 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Emad S. Alnemri is in the Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA. E_Alnemri@lac.jci.tju.edu,

    Emad S. Alnemri

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  1. Emad S. Alnemri
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Alnemri, E. HtrA2 and Parkinson's disease: think PINK?. Nat Cell Biol 9, 1227–1229 (2007). https://doi.org/10.1038/ncb1107-1227

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