Drosophila G-protein signalling: intricate roles for Ric-8?

Receptor-independent G-protein signalling regulates both the orientation and position of the mitotic spindle during asymmetric cell division. Several new studies show that the targeting of G-protein subunits to the membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and -independent pathways.

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Figure 1: Ric-8 regulates receptor-independent G-protein signalling in asymmetric cell division.

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