Receptor-independent G-protein signalling regulates both the orientation and position of the mitotic spindle during asymmetric cell division. Several new studies show that the targeting of G-protein subunits to the membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and -independent pathways.
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Matsuzaki, F. Drosophila G-protein signalling: intricate roles for Ric-8?. Nat Cell Biol 7, 1047–1049 (2005). https://doi.org/10.1038/ncb1105-1047
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DOI: https://doi.org/10.1038/ncb1105-1047