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The kinetochore NUPtials

The most interesting discoveries are often those that couple distinct fields of science in unexpected ways. The marriage of the nuclear pore complex to the kinetochore and spindle checkpoint regulation is a recent example, raising the question of why such divergent processes as mitosis and nuclear transport use common proteins.

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Figure 1: The NPC in interphase cells.
Figure 2: A model for regulation of spindle checkpoint signalling by Ran-GTP.

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Stukenberg, P., Macara, I. The kinetochore NUPtials. Nat Cell Biol 5, 945–947 (2003). https://doi.org/10.1038/ncb1103-945

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