News & Views | Published:

A family outing: small GTPases cyclin' through G1

Nature Cell Biology volume 3, pages E250E251 (2001) | Download Citation

Subjects

Cell proliferation is regulated by temporal changes in gene expression in response to specific chemical and physical cues. These signals are relayed by a variety of intracellular signalling pathways including those activated by small GTPases, such as Ras, Rho, Rac and Cdc42. In this issue, Assoian and colleagues show that Rho confines the expression of cyclin D1 to mid-G1 phase of the cell cycle, by interactions with the ERK and Rac/Cdc42 signalling pathways.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nature Cell Biol. 3, 950–957 (2001).

  2. 2.

    & Genes Dev. 13, 1501–1512 (1999).

  3. 3.

    , & Science 269, 1270–1272 (1995).

  4. 4.

    & Oncogene 18, 3085–3097 (1999).

  5. 5.

    Cell 80, 179–185 (1995).

  6. 6.

    , , , & Mol. Biol. Cell 10, 3197–3204 (1999).

  7. 7.

    & BioEssays 22, 818–826 (2000).

  8. 8.

    & Cell 70, 389–399 (1992).

  9. 9.

    & Science 285, 1028–1032 (1999).

  10. 10.

    et al. Curr. Biol. 10, 551–554 (2000).

  11. 11.

    et al. EMBO J. 16, 6426–6438 (1997).

  12. 12.

    , & J. Biol. Chem. 276, 34728–34737 (2001).

  13. 13.

    , , , & EMBO J. 19, 2008–2014 (2000).

  14. 14.

    et al. J. Biol. Chem. 274, 25245–25249 (1999).

  15. 15.

    et al. J. Cell Biol. 141, 1625–1636 (1998).

  16. 16.

    , , , & J. Cell Biol. 147, 1009–1022 (1999).

  17. 17.

    et al. Mol. Cell 8, 115–1127 (2001).

Download references

Author information

Affiliations

  1. Mathew L. Coleman and Christopher J. Marshall are in the CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, London, SW3 6JB, UK mathew@icr.ac.uk chrism@icr.ac.uk

    • Mathew L. Coleman
    •  & Christopher J. Marshall

Authors

  1. Search for Mathew L. Coleman in:

  2. Search for Christopher J. Marshall in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ncb1101-e250

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing