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Cyclin' on the viral path to destruction

Abstract

Viruses are the masters of trickery. They mimic, manipulate and usurp cellular functions, but always with an interesting twist. γ-herpesvirus genomes encode an abundance of homologues of cellular factors, including cyclin and Bcl-2. These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus.

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Figure 1: Homologues of cellular cyclins encoded by the viruses KSHV (KS) and γMH68 (γ68) bind to one or more cellular cyclin-dependent kinases (CDKs) and phosphorylate an increased number of substrates compared with their cellular counterparts, leading to degradation of these substrates.

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Hardwick, J. Cyclin' on the viral path to destruction. Nat Cell Biol 2, E203–E204 (2000). https://doi.org/10.1038/35041126

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