Abstract
Membrane trafficking depends on NSF, an ATPase that dissociates a complex of membrane proteins called SNAREs. A particular NSF mutant apparently lacks ATPase activity and cannot dissociate SNAREs, but can still promote membrane fusion in an in vitro assay. Might NSF, in certain systems, have actions we do not yet appreciate?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Block, M. R., Glick, B. S., Wilcox, C. A., Wieland, F. T. & Rothman, J. E. Proc. Natl Acad. Sci. USA 85, 7852–7856 (1988).
Sollner, T., Bennett, M. K., Whiteheart, S. W., Scheller, R. H. & Rothman, J. E. Cell 75, 409–418 (1993).
Müller, J. M. M. et al. Nature Cell Biol. 1, 335– 340 (1999).
Graham, T. R. & Emr, S. D. J. Cell. Biol. 114, 207–218 (1991).
Whiteheart, S. W. et al. J. Cell Biol. 126, 945– 954 (1994).
Mayer, A., Wickner, W. & Haas, A. Cell 85, 83–94 (1996).
Banerjee, A., Barry, V. A., DasGupta, B. R. & Martin, T. F. J. J. Biol. Chem. 271, 20223–20226 (1996).
Pallanck, L., Ordway, R. W. & Ganetzky, B. Nature 376, 25 ( 1995).
Otter-Nilsson, M., Hendriks, R., Pecheur-Huet, E. I., Hoekstra, D. & Nilsson, T. EMBO J. 18, 2074–2083 (1999).
Tolar, L. A. & Pallanck, L. J. Neurosci. 18, 10250–10256 (1998).
Littleton, J. T. et al. Neuron 21, 401–413 (1998).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Schwarz, T. NSF is up to new tricks. Nat Cell Biol 1, E141–E142 (1999). https://doi.org/10.1038/14090
Issue Date:
DOI: https://doi.org/10.1038/14090