One hit, two outcomes for VHL-mediated tumorigenesis

The tumour suppressor VHL is known to suppress hypoxia-induced gene expression by degrading HIF family transcription factors. Evidence that VHL also targets the oncoprotein β-catenin for degradation highlights a new road to transformation by loss of VHL.

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Figure 1: Regulation of β-catenin- and HIF-dependent transcription by pVHL/Jade-1 and APC.

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Behrens, J. One hit, two outcomes for VHL-mediated tumorigenesis. Nat Cell Biol 10, 1127–1128 (2008). https://doi.org/10.1038/ncb1008-1127

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