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Shaping membranes into autophagosomes

Nature Cell Biology volume 9, pages 1125–1127 (2007)Cite this article

The class III phosphatidylinositol 3-kinase (PI(3)KC3) is part of a key complex regulating autophagy. How this complex mechanistically contributes to autophagosome formation remains largely unknown. The BAR-domain-containing protein Bif-1/endophilin B1, commonly associated with the control of membrane curvature, has been identified as a new interacting partner for PI(3)KC3, suggesting the complex plays an active part in the regulation of membrane dynamics during autophagy.

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Figure 1: Autophagosome biogenesis and PI(3)K activities.
Figure 2: Schematic representation of Bif-1 indicating all the known Bif-1 interactors and the Bif-1 domain that they bind to.

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  1. Muriel Mari and Fulvio Reggiori are at the Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. F.Reggiori@umcutrecht.nl,

    Muriel Mari & Fulvio Reggiori

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  1. Muriel Mari
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  2. Fulvio Reggiori
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Mari, M., Reggiori, F. Shaping membranes into autophagosomes. Nat Cell Biol 9, 1125–1127 (2007). https://doi.org/10.1038/ncb1007-1125

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