Atg5: more than an autophagy factor

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Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now been shown that, in addition to its role in the formation of autophagosomes, an Atg5 fragment produced by calpain cleavage has pro-apoptotic properties.

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Figure 1: Partners of Atg5 and their role in autophagy and apoptosis.

References

  1. 1

    Levine, B. & Klionsky, D. J. Dev. Cell 6, 463–477 (2004).

  2. 2

    Mizushima, N. et al. Nature 395, 395–398 (1998).

  3. 3

    Yousefi, S. et al. Nature Cell Biol. 8, 1124–1132 (2006).

  4. 4

    Ichimura, Y. et al. Nature 408, 488–492 (2000).

  5. 5

    Hara, T. et al. Nature 441, 885–889 (2006).

  6. 6

    Kuma, A. et al. Nature 432, 1032–1036 (2004).

  7. 7

    Boya, P. et al. Mol. Cell Biol. 25, 1025–1040 (2005).

  8. 8

    Levine, B. & Yuan, J. J. Clin. Invest. 115, 2679–2688 (2005).

  9. 9

    Pattingre, S. et al. Cell 122, 927–939 (2005).

  10. 10

    Pyo, J. O. et al. J. Biol. Chem. 280, 20722–20729 (2005).

  11. 11

    Shimizu, S. et al. Nature Cell Biol. 6, 1221–1228 (2004).

  12. 12

    Goll, D. E. et al. Physiol. Rev. 83, 731–801 (2003).

  13. 13

    Hosokawa, N. et al. FEBS Lett 580, 2623–2629 (2006).

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