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HAUSP hunting the FOX(O)

The forkhead box O (FOXO) family of transcription factors regulate cell stress, cell cycle and cell death pathways. Their activities can be modulated by multiple posttranslational modifications, including phosphorylation and acetylation. A recent study adds a new twist to FOXO regulation, showing that coupled ubiquitination and deubiquitination of FOXO may be important for cellular responses to oxidative stress.

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Figure 1: Regulation of FOXO by monoubiquitination and deubiquitination.

References

  1. Greer, E. L. & Brunet, A. Oncogene 24, 7410–7425 (2005).

    Article  CAS  Google Scholar 

  2. Cantley, L. C. Science 296, 1655–1657 (2002).

    Article  CAS  Google Scholar 

  3. Brunet, A. et al. Science 303, 2011–2015 (2004).

    Article  CAS  Google Scholar 

  4. van der Horst, A. et al. J.Biol. Chem. 279, 28873–28879 (2004).

    Article  CAS  Google Scholar 

  5. van der Horst, A. et al. Nature Cell Biol. 1064–1073 (2006).

  6. Huang, T. T. & D'Andrea, A. D. Nature Rev. Mol. Cell Biol. 7, 323–324 (2006).

    Article  CAS  Google Scholar 

  7. Li, M. et al. Nature 416, 648–653 (2002).

    Article  CAS  Google Scholar 

  8. Cummins, J. M. & Vogelstein, B. Cell Cycle 3, 689–653 (2004).

    Article  CAS  Google Scholar 

  9. J. M. Cummins et al. Nature 428, 1 p following 486 (2004).

    Article  Google Scholar 

  10. Li, M., Brooks, C. L., Kon, N. & Gu, W. Mol. Cell 13, 879–886 (2004).

    Article  CAS  Google Scholar 

  11. Tang, J. et al. Nature Cell Biol 8, 855–862 (2006).

    Article  CAS  Google Scholar 

  12. Hu, M. et al. PLoS Biol 4, e27 (2006).

    Article  Google Scholar 

  13. Sheng, Y. et al. Nature Struct Mol Biol 13, 285–291 (2006).

    Article  CAS  Google Scholar 

  14. Nijman, S. M. et al. Mol. Cell 17, 331–339 (2005).

    Article  CAS  Google Scholar 

  15. Huang, T. T. et al. Nature Cell Biol. 8, 339–347 (2006).

    CAS  PubMed  Google Scholar 

Download references

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Huang, T., D'Andrea, A. HAUSP hunting the FOX(O). Nat Cell Biol 8, 1043–1045 (2006). https://doi.org/10.1038/ncb1006-1043

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