The forkhead box O (FOXO) family of transcription factors regulate cell stress, cell cycle and cell death pathways. Their activities can be modulated by multiple posttranslational modifications, including phosphorylation and acetylation. A recent study adds a new twist to FOXO regulation, showing that coupled ubiquitination and deubiquitination of FOXO may be important for cellular responses to oxidative stress.
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Huang, T., D'Andrea, A. HAUSP hunting the FOX(O). Nat Cell Biol 8, 1043–1045 (2006). https://doi.org/10.1038/ncb1006-1043
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DOI: https://doi.org/10.1038/ncb1006-1043