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More than a separase

Nature Cell Biology volume 7, pages 930–932 (2005)Cite this article

Anaphase onset is triggered when the protease separase cleaves the cohesive bond that holds replicated sister chromatids together until metaphase. In budding yeast, separase then also regulates mitotic exit. New findings suggest that in vertebrates, separase also participates in cell-cycle regulation, albeit in an unexpected manner.

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Figure 1: The roles of separase during mitosis.

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  1. the Cancer Research UK London Research Institute, Chromosome Segregation Laboratory, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK

    Ethel Queralt & Frank Uhlmann

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  1. Ethel Queralt
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  2. Frank Uhlmann
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Queralt, E., Uhlmann, F. More than a separase. Nat Cell Biol 7, 930–932 (2005). https://doi.org/10.1038/ncb1005-930

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