Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

Maintaining integrity

Nature Cell Biology volume 6, pages 923–928 (2004)Cite this article

Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Early events in the cellular response to double-strand breaks (DSBs) in the DNA.
Figure 2: Real-time imaging of the recruitment of signalling and repair proteins to microlaser-generated sites of DNA damage.

References

  1. Bassing, C.H. & Alt, F.W. DNA Repair (Amst.) 3, 781–796 (2004).

    Article  CAS  Google Scholar 

  2. Aylon, Y. & Kupiec, M. DNA Repair (Amst.) 3, 797–815 (2004).

    Article  CAS  Google Scholar 

  3. Lieber, M.R., Ma, Y., Pannicke, U. & Schwarz, K. DNA Repair (Amst.) 3, 817–826 (2004).

    Article  CAS  Google Scholar 

  4. Wyman, C., Ristic, D. & Kanaar, R. DNA Repair (Amst.) 3, 827–833 (2004).

    Article  CAS  Google Scholar 

  5. Abraham, R.T. DNA Repair (Amst.) 3, 883–887 (2004).

    Article  CAS  Google Scholar 

  6. Morrison, C. & Rieder, C.L. DNA Repair (Amst.) 3, 1133–1139 (2004).

    Article  CAS  Google Scholar 

  7. Lehmann, A.R. Genes Dev. 15, 15–23 (2001).

    Article  CAS  Google Scholar 

  8. Karran, P. & Bignami, M. Nucleic Acids Res. 20, 2933–2940 (1992).

    Article  CAS  Google Scholar 

  9. Lehmann, A.R. Mutat. Res. 509, 23–34 (2002).

    Article  CAS  Google Scholar 

  10. Prakash, S. & Prakash, L. Genes Dev. 16, 1872–1883 (2002).

    Article  CAS  Google Scholar 

  11. Gruber, S., Haering, C.H. & Nasmyth, K. Cell 112, 765–777 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human Genetics and Molecular Medicine, The David and Inez Myers Laboratory for Genetic Research, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Yosef Shiloh

  2. Genome Damage and Stability Centre, University of Sussex Falmer, Brighton, BN1 9RQ, UK

    Alan R. Lehmann

Authors
  1. Yosef Shiloh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alan R. Lehmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yosef Shiloh or Alan R. Lehmann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shiloh, Y., Lehmann, A. Maintaining integrity. Nat Cell Biol 6, 923–928 (2004). https://doi.org/10.1038/ncb1004-923

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1004-923

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing