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Transcriptional regulation: RUPture in the ER

Regulated ubiquitin/proteasome-dependent processing controls transcription by triggering the release of dormant transcriptional activators from the endoplasmic reticulum. This intersection of transcription and proteolysis has important implications for gene control, proteasome–substrate interactions and signal integration.

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Figure 1: RUP links fatty-acid biosynthesis to changes in ER-membrane composition.
Figure 2: Proteasome-mediated processing of membrane-tethered SPT23.


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Tansey, W. Transcriptional regulation: RUPture in the ER. Nat Cell Biol 2, E175–E177 (2000).

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