Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Wounding Smad

Nature Cell Biology volume 1, pages E117–E119 (1999)Cite this article

Abstract

TGF-β is a cytokine that enhances wound healing, a process involving diverse TGF-β-responsive cell types. Mice with a deletion of the Smad3 gene exhibit an increased rate of wound healing. The lack of Smad3 seems to modify the cellular response to TGF-β and may suggest an intriguing molecular basis to this process.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The cellular basis for the accelerated re-epithelialization and faster wound healing in Smad3-deficient mice1.
Figure 2: The Smad2 and Smad3 arms of transforming growth factor-β (TGF-β) signalling in cells at a wound site, as inferred from the TGF-β-response phenotype of three cell types from Smad3-deficient animals1.

References

  1. Ashcroft, G. S. et al. Nature Cell Biol. 1, 260–266 (1999).

    Article  CAS  Google Scholar 

  2. Massague, J. Annu. Rev. Biochem. 67, 753–791 (1998).

    Article  CAS  Google Scholar 

  3. Yang, X. et al. EMBO J. 18, 1280–1291 (1999).

    Article  CAS  Google Scholar 

  4. Datto, M. B. et al. Mol. Cell. Biol. 19, 2495–2504 (1999).

    Article  CAS  Google Scholar 

  5. Zhu, Y., Richardson, J. A., Parada, L. F. & Graff, J. M. Cell 18, 703–714 (1998).

    Article  Google Scholar 

  6. Yanagisawa, K. et al. Oncogene 17, 1743–1747 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cell Biology Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA

    Joan Massagué

Authors
  1. Joan Massagué
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Massagué, J. Wounding Smad. Nat Cell Biol 1, E117–E119 (1999). https://doi.org/10.1038/12944

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/12944

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing