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RISC hitches onto endosome trafficking

Nature Cell Biology volume 11, pages 10491051 (2009) | Download Citation

Subjects

The RNA-induced silencing complex (RISC) downregulates expression of the genes targeted by RNA-silencing pathways. But formation and turnover of the RISC complex itself is tightly regulated and requires endosomal membranes.

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References

  1. 1.

    & Nature 457, 396–404 (2009).

  2. 2.

    et al. Nature Rev. Mol. Cell Biol. 8, 9–22 (2007).

  3. 3.

    & Mol. Cell 25, 635–646 (2007).

  4. 4.

    , , , & Nature Cell Biol. 11, 1143–1149 (2009).

  5. 5.

    et al. Nature Cell Biol. 11, 1150–1156 (2009).

  6. 6.

    & Nature 458, 445–452 (2009).

  7. 7.

    et al. Traffic 3, 321–330 (2002).

  8. 8.

    et al. Nature Cell Biol. 9, 654–659 (2007).

  9. 9.

    et al. Nature Cell Biol. 10, 1470–1476 (2008).

  10. 10.

    et al. Mol. Biol. Cell. 10, 3357–3372 (1999).

  11. 11.

    et al. Bioessays 26, 616–628 (2004).

  12. 12.

    et al. RNA 15, 1282–1291 (2009).

Download references

Author information

Affiliations

  1. Haruhiko Siomi and Mikiko C Siomi are in the Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.  awa403@sc.itc.keio.ac.jp; siomim@sc.itc.keio.ac.jp

    • Haruhiko Siomi
    •  & Mikiko C Siomi

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DOI

https://doi.org/10.1038/ncb0909-1049

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