The RNA-induced silencing complex (RISC) downregulates expression of the genes targeted by RNA-silencing pathways. But formation and turnover of the RISC complex itself is tightly regulated and requires endosomal membranes.
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Siomi, H., Siomi, M. RISC hitches onto endosome trafficking. Nat Cell Biol 11, 1049–1051 (2009). https://doi.org/10.1038/ncb0909-1049
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DOI: https://doi.org/10.1038/ncb0909-1049
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