Src transforms in a Cool way

Cool-1 was previously identified as an effector of activated Cdc42 and as a regulator of epidermal growth factor receptor (EGFR) trafficking. Cool-1 has now been shown to be a phosphorylation-dependent activator of Cdc42 that contributes to transformation by Src, thus proving to be an unusually versatile signalling protein.

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Figure 1: GEFs are upstream regulators and downstream effectors of GTPases.
Figure 2: Competing Cool-1 complexes regulate EGFR.

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Peterson, J., Chernoff, J. Src transforms in a Cool way. Nat Cell Biol 8, 905–907 (2006). https://doi.org/10.1038/ncb0906-905

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