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The hand that rocks the spindle

Nature Cell Biology volume 7, pages 858–859 (2005)Cite this article

Asymmetric cell division is a fundamental process by which cells give rise to progenies with different fates. Although this mechanism is well studied in the worm and fly, mammalian asymmetric cell division is poorly understood. The finding that Gβγ and AGS3 can control mitotic spindle orientation and progenitor cell fates during mouse cortical development suggests evolutionarily conserved roles in asymmetric cell division.

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Figure 1: Gβγ and AGS3 inhibition lead to cell fate changes during the middle stage of cortical neurogenesis.

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Authors and Affiliations

  1. Department of Physiology, Howard Hughes Medical Institute, University of California, 1550 4th Street, Room GD484E, San Francisco, San Francisco, 94143-0725, CA, USA

    Chay T. Kuo & Yuh-Nung Jan

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  1. Chay T. Kuo
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  2. Yuh-Nung Jan
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Kuo, C., Jan, YN. The hand that rocks the spindle. Nat Cell Biol 7, 858–859 (2005). https://doi.org/10.1038/ncb0905-858

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