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Signalling for secretion

How proteins exit the Golgi apparatus on their way to the plasma membrane is poorly understood. Protein kinase D (PKD) is known to regulate this process, but its downstream targets have remained elusive. New work now identifies a previously known player in Golgi dynamics — phosphatidylinositol 4-kinase IIIβ — as a physiological PKD substrate.

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Figure 1: PI4KIIIβ-dependent formation of TGN-to-plasma membrane carriers.

References

  1. Van Lint, J. et al. Trends Cell Biol. 12, 193–200 (2002).

    Article  CAS  Google Scholar 

  2. Baron, C.L. & Malhotra, V. Science 295, 325–328 (2002).

    Article  CAS  Google Scholar 

  3. Diaz Anel, A.M. & Malhotra, V. J. Cell Biol. 169, 83–91 (2005).

    Article  Google Scholar 

  4. Liljedahl, M. et al. Cell 104, 409–420 (2001).

    Article  CAS  Google Scholar 

  5. Yeaman, C. et al. Nature Cell Biol. 6, 106–112 (2004).

    Article  CAS  Google Scholar 

  6. Hausser, A. et al. Nature Cell Biol. 7, 880–886 (2005).

    Article  CAS  Google Scholar 

  7. Hama, H. et al. J. Biol. Chem. 274, 34294–34300 (1999).

    Article  CAS  Google Scholar 

  8. Walch-Solimena, C. & Novick, P. Nature Cell Biol. 1, 523–525 (1999).

    Article  CAS  Google Scholar 

  9. Audhya, A. et al. Mol. Biol. Cell 11, 2673–2689 (2000).

    Article  CAS  Google Scholar 

  10. Godi, A. et al. Nature Cell Biol. 1, 280–287 (1999).

    Article  CAS  Google Scholar 

  11. Bruns, J.R., Ellis, M.A., Jeromin, A. & Weisz, O.A. J. Biol. Chem. 277, 2012–2018 (2002).

    Article  CAS  Google Scholar 

  12. Doppler, H. et al. J. Biol. Chem. 280, 15013–15019 (2005).

    Article  Google Scholar 

  13. Godi, A. et al. Nature Cell Biol. 6, 393–404 (2004).

    Article  CAS  Google Scholar 

  14. de Graaf, P. et al. Mol. Biol. Cell. 15, 2038–2047 (2004).

    Article  CAS  Google Scholar 

  15. Wang, Y.J. et al. Cell 114, 299–310 (2003).

    Article  CAS  Google Scholar 

  16. Bonazzi, M. et al. Nature Cell Biol. 7, 570–580 (2005).

    Article  CAS  Google Scholar 

Download references

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Ghanekar, Y., Lowe, M. Signalling for secretion. Nat Cell Biol 7, 851–853 (2005). https://doi.org/10.1038/ncb0905-851

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