How proteins exit the Golgi apparatus on their way to the plasma membrane is poorly understood. Protein kinase D (PKD) is known to regulate this process, but its downstream targets have remained elusive. New work now identifies a previously known player in Golgi dynamics — phosphatidylinositol 4-kinase IIIβ — as a physiological PKD substrate.
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Ghanekar, Y., Lowe, M. Signalling for secretion. Nat Cell Biol 7, 851–853 (2005). https://doi.org/10.1038/ncb0905-851
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DOI: https://doi.org/10.1038/ncb0905-851
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