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Kip1 meets SKP2: new links in cell-cycle control

Nature Cell Biology volume 1, pages E91–E93 (1999)Cite this article

Abstract

The cyclin-dependent kinase inhibitor p27Kip1 is degraded in a phosphorylation- and ubiquitin-dependent way upon cell-cycle entry. p45SKP2, the adaptor subunit of the ubiquitin–protein ligase SCFSKP2, may mediate recognition and ubiquitination of phosphorylated p27Kip1.

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Figure 1: The SCFSKP2 ubiquitin–ligase (E3) complex associated with phosphorylated p27.
Figure 2: Hypothetical representation of the regulatory events discussed here.

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Authors and Affiliations

  1. the Swiss Institute for Experimental Cancer Research, Epalinges, CH-1066, Switzerland

    Bruno Amati & Jaromir Vlach

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  1. Bruno Amati
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  2. Jaromir Vlach
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Correspondence to Bruno Amati.

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Amati, B., Vlach, J. Kip1 meets SKP2: new links in cell-cycle control. Nat Cell Biol 1, E91–E93 (1999). https://doi.org/10.1038/12087

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