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Axon growth-stimulus package includes local translation

Nature Cell Biology volume 11, pages 919921 (2009) | Download Citation

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Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.

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Affiliations

  1. Ian G. Macara, Hidekazu Iioka and Stavroula Mili are in the Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908-0577, USA.  igm9c@virginia.edu

    • Ian G. Macara
    • , Hidekazu Iioka
    •  & Stavroula Mili

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DOI

https://doi.org/10.1038/ncb0809-919

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