Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both oncogene-induced and replicative senescence.
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Bartek, J., Hodny, Z. & Lukas, J. Cytokine loops driving senescence. Nat Cell Biol 10, 887–889 (2008). https://doi.org/10.1038/ncb0808-887
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DOI: https://doi.org/10.1038/ncb0808-887
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