Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

It takes guts to make a single lumen

Nature Cell Biology volume 9, pages 880–881 (2007)Cite this article

A new study of the zebrafish intestine has uncovered a transcriptional hierarchy controlling lumen formation and proposes a model for how transcellular and paracellular transport synergize to ensure that only a single lumen is produced.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The single luminal space of the zebrafish intestine and neural tube are formed in discrete steps.
Figure 2: The luminal space in the intestine expands by ion and water transport through transcellular and paracellular routes.

References

  1. Bagnat, M. et al. Nature Cell Biol. 9, 954–960 (2007).

    Article  CAS  Google Scholar 

  2. Horne-Badovinac, S. et al. Curr Biol. 11, 1492–1502 (2001).

    Article  CAS  Google Scholar 

  3. Furuse, M. & Tsukita, S. Trends Cell Biol. 16, 181–188 (2006).

    Article  CAS  Google Scholar 

  4. Van Itallie, C.M. & Anderson, J. M. Annu. Rev. Physiol. 68, 403–429 (2006).

    Article  CAS  Google Scholar 

  5. Montesano, R. & Soulis, P. J. Cell Sci. 115, 4419–4431 (2002).

    Article  CAS  Google Scholar 

  6. O´Brien, L. E. et al. Nature Rev. Mol. Cell. Biol. 3, 531–537 (2002).

    Article  Google Scholar 

  7. Lowery, L. A. & Sive, H. Development 132, 2057–2067 (2005).

    Article  CAS  Google Scholar 

  8. Tawk M, A. C. et al. Nature 446, 797–800 (2007).

    Article  Google Scholar 

  9. Kroschewski, R. News Physiol. Sci. 19, 61–66 (2004).

    PubMed  Google Scholar 

  10. Husain, N. et al. Dev. Cell 11, 483–493 (2006).

    Article  CAS  Google Scholar 

  11. Tonning, A. et al. Dev. Cell 9, 423–430 (2005).

    Article  CAS  Google Scholar 

  12. Luschnig, S. et al. Curr. Biol. 16, 186–194 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Heinz-Georg Belting and Markus Affolter are in Growth and Development, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland Markus.Affolter@unibas.ch,

    Heinz-Georg Belting & Markus Affolter

Authors
  1. Heinz-Georg Belting
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Markus Affolter
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Belting, HG., Affolter, M. It takes guts to make a single lumen. Nat Cell Biol 9, 880–881 (2007). https://doi.org/10.1038/ncb0807-880

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0807-880

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing