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Debugging cellular reprogramming

Nature Cell Biology volume 9, pages 871873 (2007) | Download Citation

Last year it was reported that a cocktail of four transcription factors — encoded by Oct4, Sox2, Myc and Klf4 — can partly reprogramme mouse somatic cells to an embryonic state, a process that reawakens silenced segments of the genome and restores pluripotency to the somatic cell nucleus. Three groups have now modified this method to generate fully reprogrammed cells that closely resemble embryonic stem cells.

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Author information

Affiliations

  1. In-Hyun Park is in the Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA.

    • In-Hyun Park
  2. George Q. Daley is in the Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA, Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA, and Harvard Stem Cell Institute, Boston, MA 02115, USA. George.Daley@childrens.harvard.edu

    • George Q. Daley

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Competing interests

The authors declare no competing financial interests.

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DOI

https://doi.org/10.1038/ncb0807-871

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