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EGFR trafficking: parkin' in a jam

Nature Cell Biology volume 8, pages 787–788 (2006)Cite this article

Ubiquitin, best known as a degradation signal, is also a protein-sorting tag on endocytic cargoes and a regulatory switch on endocytic adaptor proteins. Parkin, a ubiquitin ligase whose mutations are associated with Parkinson's disease, has now been shown to control EGF-receptor internalization and Akt signalling by ubiquitination of the endocytic scaffold protein Eps15.

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Figure 1: Model of parkin-mediated monoubiquitination of Eps15.

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  1. the Institute for Biochemistry II, Goethe University Medical School, Frankfurt, 60590, Germany

    Koraljka Husnjak & Ivan Dikic

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  1. Koraljka Husnjak
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  2. Ivan Dikic
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Husnjak, K., Dikic, I. EGFR trafficking: parkin' in a jam. Nat Cell Biol 8, 787–788 (2006). https://doi.org/10.1038/ncb0806-787

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