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Loss of Dicer fowls up centromeres

Nature Cell Biology volume 6, pages 696–697 (2004)Cite this article

Centromeres, specialized regions on chromosomes, are essential for accurate chromosome segregation during cell division. In fission yeast, the RNA interference machinery has a pivotal function in the assembly of centromeric heterochromatin, which mediates sister centromere cohesion. Studies in vertebrate cells now suggest that many aspects of this process are conserved.

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Figure 1: A model for RNAi-mediated heterochromatin assembly in vertebrates.

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  1. The Wellcome Trust Centre for Cell Biology, The Michael Swann Building, University of Edinburgh, Edinburgh, EH9 3JR, UK

    Sharon A. White & Robin C. Allshire

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  1. Sharon A. White
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  2. Robin C. Allshire
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White, S., Allshire, R. Loss of Dicer fowls up centromeres. Nat Cell Biol 6, 696–697 (2004). https://doi.org/10.1038/ncb0804-696

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