Cdc14 is a phosphatase that can antagonize CDK/cyclin cell-cycle functions. New insights from Caenorhabditis elegans show that CDC-14 is required to prevent cell-cycle entry during extended periods of developmentally regulated quiescence, and also clarify its role in creating the central mitotic spindle during anaphase.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Murray, A.W. Cell 116, 221–234 (2004).
Gray, C.H., Good, V.M., Tonks, N.K. & Barford, D. EMBO J. 22, 3524–3535 (2003).
Trautmann, S. & McCollum, D. Curr. Biol. 12, R733–R735 (2002).
Pereira, G. & Schiebel, E. Nature Cell Biol. 6, 473–475 (2004).
Gruneberg, U., Glotzer, M., Gartner, A. & Nigg, E.A. J. Cell Biol. 158, 901–914 (2002).
Saito, R.M. et al. Nature Cell Biol. 6, 777–783 (2004).
Lee, L.A. & Orr-Weaver, T.L. Annu. Rev. Genet. 37, 545–578 (2003).
Hong, Y., Roy, R. & Ambros, V. Development 125, 3585–3597 (1998).
Slingerland, J. & Pagano, M. J. Cell. Physiol. 183, 10–17 (2000).
Kaiser, B.K., Zimmerman, Z.A., Charbonneau, H. & Jackson, P.K. Mol. Biol. Cell 13, 2289–2300 (2002).
Wong, A.K. et al. Genomics 59, 248–251 (1999).
Mishima, M., Kaitna, S. & Glotzer, M. Dev. Cell 2, 41–54 (2002).
Mishima, M. et al. Nature DOI: 10.1038/nature02767 (2004).
Sijen, T. et al. Cell 107, 465–476 (2001).
Tijsterman, M. et al. Science 295, 694–697 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kipreos, E. Developmental quiescence: Cdc14 moonlighting in G1. Nat Cell Biol 6, 693–695 (2004). https://doi.org/10.1038/ncb0804-693
Issue Date:
DOI: https://doi.org/10.1038/ncb0804-693
