Closing in on vertebrate planar polarity

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Convergent extension — a key tissue movement during vertebrate embryogenesis — requires precise control of cell polarity, which is regulated through a planar cell polarity pathway that is conserved across invertebrates. The identification of two new factors regulating convergent extension suggests that vertebrates may have introduced intriguing modifications of the planar cell polarity pathway to regulate morphogenesis.

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Figure 1: Convergent extension and planar polarity.
Figure 2: The vertebrate planar cell polarity cascade — simplified.

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Wallingford, J. Closing in on vertebrate planar polarity. Nat Cell Biol 6, 687–689 (2004) doi:10.1038/ncb0804-687

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