From chromatin to cancer: a new histone lysine methyltransferase enters the mix

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Disruption of post-translational modifications of histone proteins perturbs the proper pattern of gene expression and has the potential to result in diseases, such as cancer. A study implicating a new histone lysine methyltransferase in tumorigenesis further corroborates the emerging link between cancer and epigenetics.

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Figure 1: Potential model for SMYD3-mediated histone H3-K4 methylation.
Figure 2: Model for cellular transformation by high levels of SMYD3.

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Sims, R., Reinberg, D. From chromatin to cancer: a new histone lysine methyltransferase enters the mix. Nat Cell Biol 6, 685–687 (2004) doi:10.1038/ncb0804-685

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