Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cdk5 is a dynamo at the synapse

Nature Cell Biology volume 5, pages 689–690 (2003)Cite this article

Synaptic vesicle recycling is a highly regulated process that involves the coordinated function of several different presynaptic proteins including the dephosphins, whose dephosphorylation is important for triggering endocytosis. Subsequent rounds of endocytosis then depend on rephosphorylation of dephosphins. Recent work establishes Cdk5 as a dephosphin kinase whose function is necessary for synaptic vesicle endocytosis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The phosphorylation/de-phosphorylation cycle in synaptic vesicle endocytosis.

References

  1. Slepnev, V.I. & De Camilli, P. Nature Rev. Neurosci. 1, 161–172 (2000).

    Article  CAS  Google Scholar 

  2. Brodin, L., Low, P. & Shupliakov, O. Curr. Opin. Neurobiol. 10, 312–320 (2000).

    Article  CAS  Google Scholar 

  3. Cousin, M.A. & Robinson, P.J. Trends Neurosci. 24, 659–665 (2001).

    Article  CAS  Google Scholar 

  4. Tan, T.C. et al. Nature Cell Biol. 5, 701–710 (2003).

    Article  CAS  Google Scholar 

  5. Dhavan, R. & Tsai, L.H. Nature Rev. Mol. Cell Biol. 2, 749–759 (2001).

    Article  CAS  Google Scholar 

  6. Sharma, S.K. et al. Dev. Biol. 247, 1–10 (2002).

    Article  CAS  Google Scholar 

  7. Lee, J. et al. Curr. Biol. 8, 1310–1321 (1998).

    Article  CAS  Google Scholar 

  8. Tomizawa, K. et al. J. Neurosci. 22, 2590–2597 (2002).

    Article  CAS  Google Scholar 

  9. Floyd, S.R. et al. J. Biol. Chem. 276, 8104–8110 (2001).

    Article  CAS  Google Scholar 

  10. Shuang, R. et al. J. Biol. Chem. 273, 4957–4966 (1998).

    Article  CAS  Google Scholar 

  11. Matsubara, M. et al. J. Biol. Chem. 271, 21108–21113 (1996).

    Article  CAS  Google Scholar 

  12. Powell, K.A. et al. J. Biol. Chem. 275, 11610–11617 (2000).

    Article  CAS  Google Scholar 

  13. Slepnev, V.I. et al. Nature 281, 821–824 (1998).

    CAS  Google Scholar 

  14. Schuman, E.M. & Murase, S. Phil. Trans. R. Soc. Lond. B 358, 749–756 (2003).

    Article  CAS  Google Scholar 

  15. Liu, F. et al. Proc. Natl Acad. Sci. USA 98, 11062–11068 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Harvard Medical School and the Program in Neuroscience, Harvard University, 200 Longwood Avenue, Boston, 02115, MA, USA

    Benjamin Adam Samuels

  2. Department of Pathology, Harvard Medical School, the Program in Neuroscience, Harvard University and Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, 02115, MA, USA

    Li-Huei Tsai

Authors
  1. Benjamin Adam Samuels
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li-Huei Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Samuels, B., Tsai, LH. Cdk5 is a dynamo at the synapse. Nat Cell Biol 5, 689–690 (2003). https://doi.org/10.1038/ncb0803-689

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0803-689

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing