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Chromosome instability: lessons from HIV

Nature Cell Biology volume 4, pages E191–E193 (2002)Cite this article

Modulating the cell cycle is essential for viral replication and infection. HIV is an expert at manipulating these processes. New work now shows how apoptosis of CD4/CXCR4-expressing T cells during the course of HIV-infection is intimately connected to aberrant cell-cycle regulation.

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Figure 1: Model of HIV-induced syncytial apoptosis.

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Authors and Affiliations

  1. Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333, ZA, The Netherlands

    Jan Paul Medema

  2. Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066, CX, The Netherlands

    René H. Medema

Authors
  1. Jan Paul Medema
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  2. René H. Medema
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Medema, J., Medema, R. Chromosome instability: lessons from HIV. Nat Cell Biol 4, E191–E193 (2002). https://doi.org/10.1038/ncb0802-e191b

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