News & Views | Published:

Multi-talented MCAK: Microtubule depolymerizer with a strong grip

Nature Cell Biology volume 13, pages 738740 (2011) | Download Citation

Microtubule-depolymerizing motor proteins regulate microtubule dynamics during chromosome segregation, but whether they can independently grip the ends of shrinking kinetochore microtubules has remained unresolved. MCAK, a member of the kinesin-13 motor protein family, is now shown to grip microtubules on its own and harness the forces of microtubule disassembly.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nature 427, 364–370 (2004).

  2. 2.

    & J. Cell Biol. 128, 95–104 (1995).

  3. 3.

    , , , & Nature 441, 115–119 (2006).

  4. 4.

    & Cell. Mol. Life Sci. 67, 2231–2250 (2010).

  5. 5.

    , , & J. Cell Sci. 123, 3425–3434 (2010).

  6. 6.

    , & Trends Cell Biol. 21, 38–46 (2011).

  7. 7.

    & Biophys. J. 83, 42–58 (2002).

  8. 8.

    , , , & Nat. Cell Biol. 13, 846–852 (2011).

  9. 9.

    , , & Cell 96, 69–78 (1999).

  10. 10.

    et al. Mol. Cell 9, 903–909 (2002).

  11. 11.

    , et al. Cell 132, 79–88 (2008).

  12. 12.

    & Nature 461, 125–128 (2009).

  13. 13.

    , , & Nat. Struct. Mol. Biol. 17, 77–82 (2010).

  14. 14.

    et al. Cell 136, 865–875 (2009).

  15. 15.

    et al. Mol. Biol. Cell 20, 963–972 (2009).

Download references

Author information

Affiliations

  1. Stefan Diez is at B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden and Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

    • Stefan Diez

Authors

  1. Search for Stefan Diez in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Stefan Diez.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ncb0711-738

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing