News & Views | Published:

Might makes right: Using force to align the mitotic spindle

Nature Cell Biology volume 13, pages 736738 (2011) | Download Citation

Both symmetric and asymmetric divisions rely on alignment of the mitotic spindle with cues from the environment. A study now shows that mitotic spindles find their position by reading the map of forces that load-bearing retraction fibres exert on the cell body.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Cell Biol. 13, 771–778 (2011).

  2. 2.

    et al. Nature 382, 420–425 (1996).

  3. 3.

    & Trends Cell Biol. 19, 174–179 (2009).

  4. 4.

    et al. Nature 469, 226–230 (2011).

  5. 5.

    & EMBO J. 26, 1487–1498 (2007).

  6. 6.

    et al. Nature 447, 493–496 (2007).

  7. 7.

    et al. J. Cell Biol. 191, 453–462 (2010).

  8. 8.

    et al., Curr. Biol. 21, 606–611 (2010).

  9. 9.

    et al. J. Cell Biol. 182, 77–88 (2008).

  10. 10.

    & Nat. Cell Biol. 11, 365–374 (2009).

  11. 11.

    et al. PLoS One 5, e12301 (2010).

  12. 12.

    & Proc. Natl. Acad. Sci. USA 108, 137–142 (2011).

  13. 13.

    & Dev. Growth Differ. 28, 143–156 (1986).

  14. 14.

    et al. Cell 144, 427–438 (2011).

  15. 15.

    et al. Curr. Biol. 17, 683–688 (2007).

  16. 16.

    et al. Genes Dev. 25, 131–136 (2011).

Download references

Author information

Affiliations

  1. Oscar M. Lancaster and Buzz Baum are in the MRC Laboratory of Molecular Cell Biology, UCL, Gower Street, London, WC1E 6BT

    • Oscar M. Lancaster
    •  & Buzz Baum

Authors

  1. Search for Oscar M. Lancaster in:

  2. Search for Buzz Baum in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Buzz Baum.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ncb0711-736

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing