Tumour suppressors of the Forkhead box O (FoxO) family are proposed to limit tumour growth through direct transcriptional regulation. Cytosolic FoxO1 can also suppress tumour growth by triggering autophagy and ultimately cell death in a transcription-independent manner.
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Medema, R., Jäättelä, M. Cytosolic FoxO1: alive and killing. Nat Cell Biol 12, 642–643 (2010). https://doi.org/10.1038/ncb0710-642
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DOI: https://doi.org/10.1038/ncb0710-642
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