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Delta traffic takes a sh-Arp turn

Nature Cell Biology volume 11, pages 791793 (2009) | Download Citation

In the Notch pathway, the transmembrane ligand Delta is internalized and then re-established on the surface of signal-sending cells to allow the productive binding and activation of the Notch receptor on neighbouring cells. Arp2/3-dependent actin polymerization directs Delta trafficking through this circuit.

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Author information

Affiliations

  1. Eyal D. Schejter is in the Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.  eyal.schejter@weizmann.ac.il

    • Eyal D. Schejter

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DOI

https://doi.org/10.1038/ncb0709-791

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