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Opposing roles for glypicans in Hedgehog signalling

Nature Cell Biology volume 10, pages 761–763 (2008)Cite this article

Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions.

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Figure 1: Opposite outcome for glypicans in Hh signalling.

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Authors and Affiliations

  1. Dong Yan and Xinhua Lin are in the Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. xinhua.lin@cchmc.org,

    Dong Yan & Xinhua Lin

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  1. Dong Yan
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  2. Xinhua Lin
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Yan, D., Lin, X. Opposing roles for glypicans in Hedgehog signalling. Nat Cell Biol 10, 761–763 (2008). https://doi.org/10.1038/ncb0708-761

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