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p63: revving up epithelial stem-cell potential

As legends go, when Alexander the Great crossed the Land of Darkness searching for the elixir of life, he encountered only desert. Thousands of years later, is it too optimistic to think that scientists have finally found the secret to a longer life? A recent study suggests that p63 may be key, at least for many epithelial stem cells.

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Figure 1: Postulated roles for p63 in the development of a stratified epithelium.
Figure 2: Potential mechanisms for p63 maintaining stem-cell populations.

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Acknowledgements

We thank V. Horsley for her critical reading of this manuscript.

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Blanpain, C., Fuchs, E. p63: revving up epithelial stem-cell potential. Nat Cell Biol 9, 731–733 (2007). https://doi.org/10.1038/ncb0707-731

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