Viral entry: a detour through multivesicular bodies

Many viruses and toxins enter the cytoplasm of cells by crossing endosomal membranes. New evidence now suggests that if entry occurs through multivesicular bodies, then they are first delivered into intraluminal vesicles before their final transfer into the cytoplasm via the 'back-fusion' of these vesicles.

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Figure 1: Membrane dynamics at the MVB.

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