Understanding the regulation of β-catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for β-catenin's nuclear localization, thereby promoting its transcriptional activity.
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Tolwinski, N., Wieschaus, E. A nuclear escort for β-catenin. Nat Cell Biol 6, 579–580 (2004). https://doi.org/10.1038/ncb0704-579
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DOI: https://doi.org/10.1038/ncb0704-579
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