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Tangled NUDELs?

NUDEL was first identified as a protein required for nuclear migration in filamentous fungi. Now, a study shows that it is important for normal assembly of neurofilaments in the mammalian nervous system. In utero knockdown of NUDEL expression results in disruption of neurofilament organization.

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Figure 1: Model for the role of NUDEL and microtubule motors in the axonal transport of neurofilaments.

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Holzbaur, E. Tangled NUDELs?. Nat Cell Biol 6, 569–570 (2004). https://doi.org/10.1038/ncb0704-569

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